|
Figure 2
Schematic model of Ca2+ signaling via CaM. A stimulus (top, in red) that produces Ca2+ oscillations of a certain amplitude and frequency will activate different CaM-regulated proteins differentially (bottom, in blue and green) depending on the relative affinities of the CaM-target protein complexes, the abundance of the target proteins and the degree of activation mediated by CaM. The combination of these activities in conjunction with other signaling pathways triggered by the stimulus yields the ultimate physiological response to the stimulus.
|
